Marketing chief Joel Ewanick says the company won't run ads during the big game in February.
Ewanick said in a statement Friday that GM can't justify the expense because of a significant price increase for next year's event.
The move comes as the company reviews its global advertising budget. GM spent about $4.5 billion on advertising last year.
The Super Bowl is advertising's biggest stage. Companies spent an average of $3.5 million for a 30-second commercial during this year's game.
It's not the first advertising change this week for GM. The company also decided to pull $10 million in ads from Facebook, saying they weren't effective.