The statement Thursday says Sue and Jay Paterno do not plan to comment during the trial out of respect for the legal process.
Family spokesman Wick Sollers' statement says the family will not say anything during litigation "unless something exceptional and unexpected develops."
The scandal engulfed the university following the former assistant's arrest and led to Paterno's ouster as football coach. He died of lung cancer in January.
Sollers says the late coach told his family to "pursue the truth, while forcefully defending the honor and integrity of Penn State" and all those associated with the university.